Regulation of Gene Expression
1. How is the expression of genes regulated
2. The Control of Gene Expression in Eukaryotes
- Describe the basic concept of how operons regulate the
of genes. How do components of the operon interact to control the
expression of genes?
- How do the two types of negative gene regulation (repressible
operons vs. inducible operons) differ?
- How does positive gene regulation differ from negative
- Other than through the regulation of gene expression, how else
(and other organisms) regulate metabolic pathways in cells?
- What are the major steps that must take place in order for the
encoded within a gene to be used in the production of a functional
Which of these steps serves as a potential control point for the
of gene expression?
- Even though all of the cells within an organism have the same
cell types often synthesize different proteins. Why?
- What role does DNA methylation play in regulating the
activity of genes?
- What are transcription factors and how are they able to
changes in gene expression?
- How do the post-transcriptional mechanisms of alternative
degradation of the mRNA, and protein processing and degradation help
the levels of a particular protein within a cell?
The Molecular Biology of Cancer
- How is the DNA packaged within chromatin and
What are nucleosomes, and how are histone proteins
in the formation of these structures? What is the overall organization
of DNA within chromatin and chromosomes?
- What are proto-oncogenes, oncogenes, and tumor-suppressor
genes? What are some of the most common functions of
in normal cells? What causes a proto-oncogene to become an
and how might such a transition lead to the formation of cancer?
Why is the development of cancer believed ot be a multi-step process?