Osteoporosis
Articles
"Restoring
Aging Bones". Rosen, C.L. Scientific
American. March
2003., pp.55-63.
Osteoporosis affects 10 million Americans, especially
post-menopausal
women. Half of all post-menopausal women will incur an
osteoporosis-related fracture during their lifetime. Drugs
are
available to restore bone loss and reduce the chance of additional
fractures. A new diagnostic tool, dual-energy x-ray
absoptiometry
(DEXA), measures bone mineral density at sites susceptible to
fracture. Genetics are now known to greatly influence the
likelihood of fractures and bone density loss. Essentially,
the
entire skeletal system replaces itself every 10 years. This
remodeling is done by osteoblasts and osteoclasts.
Scientists are
studying the bone remodeling in hopes of creating drugs that
control
the loss of bone density. A new therapy using synthetic
estrogen
may be on the way, which will help post-menopausal women who no
longer
produce estrogen naturally. The parathyroid hormone can be
considered the driving force behind osteoporosis, as it promotes
the
action of osteoclasts.